In the bird kingdom of Central, survival is a daily struggle, with the weak often falling prey to the ruthless. Born without wings, Astro faces an uphill battle from the start.

Amidst the chaos, a mysterious serum unleashed by Phase Pharmaceuticals alters the fate of both Astro and Crowbar, unleashing unforeseen consequences that will reshape both their world and humanity forever.

In issue one, a mysterious character from the past returns to haunt Astro's family, kickstarting the series and launching Astro on a path of vengeance.